The Loewith lab investigates the structures, functions and regulation of the two, broadly conserved, target of rapamycin (TOR) protein complexes. They use a combination of yeast genetics, cell biology, structural biology, chemical biology and biochemistry approaches and are particularly interested in how TOR complexes form higher order helical structures and how they are regulated downstream of mechanical changes in membrane tension.
Beat Fierz lab focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.
Pablo Rivera-Fuentes lab, draws from the fields of organic synthesis, molecular biology, protein engineering, single-molecule imaging, and artificial intelligence to develop small-molecule and protein tools to study the subcellular compartementalization of biological processes. Current research lines in our lab include the characterization of the redox states of mammalian organelles, the creation of chemigenetic markers and sensors for in vivo imaging, and the development of single-molecule peptide and protein identification technologies.
Yimon Aye’s research interests focuses on redox-dependent cell signaling, as well as proteins/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents.
The Boland lab aims to study the molecular mechanisms that underlie cell cycle regulation as well as signal transduction by membrane proteins in health and diseasework at the intersection of Structural Biology, Molecular & Cell Biology and Chemical Biology. Their research leverages the latest developments in cryogenic electron microscopy (cryoEM) and uses complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.).
Pierre Gönczy’s main research interests lie in understanding fundamental cell division processes, notably in the context of a developing organism and with a focus on the mechanisms governing centriole biogenesis and centrosome duplication as well as asymmetric cell division, a crucial phenomena for generating cellular diversity during development and in stem cell lineages.
The ultimate goal of Christian Heinis lab is the development of therapeutics by developing peptide macrocycles for potential therapeutic application using phase based strategy and biological and chemical tools. His lab currently develops potent antagonists to a range of disease targets, following medical indications in which bicyclic peptides promise advantages over small molecules and monoclonal antibodies.
Sascha Hoogendoorn lab aims to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.
Lang’s general research interests strive to develop new tools to study and control biological systems. Her group is especially active in enabling and advancing approaches to expand the genetic code and in developing new in vivo chemistries that are amenable to physiological conditions. This combination is ideally suited to address unmet challenges in studying and manipulating biological processes with a new level of spatial, temporal and molecular precision.
Research in the Milton Group seeks to couple metalloenzymes that catalyze important reductive reactions to electrodes, in order to study their electron transfer/catalytic mechanisms and ultimately aid the development of new biotechnologies (and bio-inspired technologies).
Aurélien Roux main research interest explores the common biological and mechanical mechanisms by which surfaces formed by cell monolayers or lipid bilayers are deformed during physiological processes such as membrane traffic, endocytosis, cell-division, cell migration and others.
The Schuhmacher Lab is interested in answering outstanding questions in membrane biology. Their chemical biology approach opens the door to investigate the so far mostly invisible and thus secret work of lipids. In particular, they would like to understand the biological role of lipid diversity and their impact on signaling processes.
Angela Steinauer’s lab focuses on the engineering of non-viral, protein-based nanocarriers for targeted RNA delivery. Inspired by viral nucleic acid-protein assemblies, her group adopts a bottom-up approach and utilizes protein design, biomolecular engineering, and directed evolution to construct carriers with tailored functionalities.
The Thomä lab focuses on the structure and function of macromolecular machines at the interface of chromatin biology and ubiquitin biology. Recent work from the laboratory illustrated how transcription factor operate in the context of chromatin, and how endogenous and synthetic small molecules drive the degradation of transcription factors and other cellular proteins by leveraging the ubiquitin proteasome system.
The Academic Chemical Screening platform of Switzerland (ACCESS), led by Gerardo Turcatti, provides the scientific community with chemical diversity, screening facilities, medicinal chemistry and know-how in chemical genetics.
The Winssinger lab makes use of small molecules and chemistry techniques to probe biological mechanisms. To accelerate probe discovery, the lab has pioneered DNA-encoded library technologies and has extended this technique to fold peptides in constricted conformations and are applying this approach to mimic affinity proteins. Their research has also pioneered proximity-enabled chemistries and used it to image oligonucleotides in cellulo or in vivo, turn-on drugs in response to biomarkers and more generally develop methodology for logic-gated responses. As part of this program, the Winssinger lab is developing photocatalytic reactions in chemical biology and using bioluminescence as a light source for photochemistry.