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Sascha Hoogendoorn

Sascha Hoogendoorn (President)

Department of Organic Chemistry, UNIGE

Sascha Hoogendoorn lab aims to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.

Sascha Hoogendoorn (President)
Beat Fierz

Beat Fierz (Vice-President)

Chemical Sciences and Engineering, EPFL

Beat Fierz lab focuses on the study of the structure, dynamics and function of chromatin and related multi-protein complexes in vitro and in cells. These investigations require an interdisciplinary approach at the interface of chemistry, biology and biophysics.

Beat Fierz (Vice-President)
Robbie Loewith

Robbie Loewith (Treasurer)

Department of Molecular Biology & Cellular biology, UNIGE

The Loewith lab investigates the structures, functions and regulation of the two, broadly conserved, target of rapamycin (TOR) protein complexes. They use a combination of yeast genetics, cell biology, structural biology, chemical biology and biochemistry approaches and are particularly interested in how TOR complexes form higher order helical structures and how they are regulated downstream of mechanical changes in membrane tension.

Robbie Loewith (Treasurer)
Pabl Rivera-Fuentes

Pablo Rivera-Fuentes

Laboratory of Chemical and Biological Probes, University of Zurich

Pablo Rivera-Fuentes lab, draws from the fields of organic synthesis, molecular biology, protein engineering, single-molecule imaging, and artificial intelligence to develop small-molecule and protein tools to study the subcellular compartementalization of biological processes. Current research lines in our lab include the characterization of the redox states of mammalian organelles, the creation of chemigenetic markers and sensors for in vivo imaging, and the development of single-molecule peptide and protein identification technologies.

Pablo Rivera-Fuentes
Andreas Boland

Andreas Boland

Department of Molecular Biology & Cellular biology, UNIGE

The Boland lab aims to study the molecular mechanisms that underlie cell cycle regulation as well as signal transduction by membrane proteins in health and diseasework at the intersection of Structural Biology, Molecular & Cell Biology and Chemical Biology. Their research leverages the latest developments in cryogenic electron microscopy (cryoEM) and uses complementary biophysical techniques (proteomics, light-microscopy, microfluidics, etc.).

Andreas Boland

Alessandro De Simone

Department of Genetics and Evolution, UNIGE

De Simone’s lab is interested in the physical principles underlying vertebrate regeneration. His group uses high-sensitivity sensors and reporters to visualise signals, forces and cell dynamics as well as analyse data using automated quantification methods.

Alessandro De Simone
Anne-Claude Gavin

Anne-Claude Gavin

CMU, University of Geneva

Pioneering in the development of novel (bio)chemical methods to map cellular protein-lipid interaction networks, the Gavin group has a strong research interest in the study of lipid metabolism and the regulation of cellular membranes homeostasis, with a special focus on the machinery involved in the creation and maintenance of lipid gradients in eukaryotic cells, and the study of mechanisms by which lipid signatures are sensed and “read” by effector proteins.

Anne-Claude Gavin
Pierre Gonczy

Pierre Gönczy

School of Life Sciences, EPFL

Pierre Gönczy’s main research interests lie in understanding fundamental cell division processes, notably in the context of a developing organism and with a focus on the mechanisms governing centriole biogenesis and centrosome duplication as well as asymmetric cell division, a crucial phenomena for generating cellular diversity during development and in stem cell lineages.

Pierre Gönczy
Christian Heinis

Christian Heinis

Chemical Sciences and Engineering, EPFL

The ultimate goal of Christian Heinis lab is the development of therapeutics by developing peptide macrocycles for potential therapeutic application using phase based strategy and biological and chemical tools. His lab currently develops potent antagonists to a range of disease targets, following medical indications in which bicyclic peptides promise advantages over small molecules and monoclonal antibodies.

Christian Heinis
Kathrin Lang

Kathrin Lang

Department of Chemistry and Applied Biosciences, ETH Zurich

Lang’s general research interests strive to develop new tools to study and control biological systems. Her group is especially active in enabling and advancing approaches to expand the genetic code and in developing new in vivo chemistries that are amenable to physiological conditions. This combination is ideally suited to address unmet challenges in studying and manipulating biological processes with a new level of spatial, temporal and molecular precision.

Kathrin Lang

Sophie Martin

Dept. of Molecular and Cellular Biology , UNIGE

Sophie Martin lab aims to understand in molecular detail how cells polarize, organize their cytoskeleton and their membrane to achieve growth, division and fusion. To this end, they use a combination of quantitative live-cell imaging, electron microscopy, genetic and biochemical approaches.

Sophie Martin

Ross Milton

Department of Inorganic and Analytical Chemistry, UNIGE

Research in the Milton Group seeks to couple metalloenzymes that catalyze important reductive reactions to electrodes, in order to study their electron transfer/catalytic mechanisms and ultimately aid the development of new biotechnologies (and bio-inspired technologies).

Ross Milton
Aurélien Roux

Aurélien Roux

Biochemistry Department, UNIGE

Aurélien Roux main research interest explores the common biological and mechanical mechanisms by which surfaces formed by cell monolayers or lipid bilayers are deformed during physiological processes such as membrane traffic, endocytosis, cell-division, cell migration and others. 

Aurélien Roux
Milena Maria Schuhmacher

Milena Schuhmacher

School of Life Sciences, EPFL

The Schuhmacher Lab is interested in answering outstanding questions in membrane biology. Their chemical biology approach opens the door to investigate the so far mostly invisible and thus secret work of lipids. In particular, they would like to understand the biological role of lipid diversity and their impact on signaling processes.

Milena Schuhmacher
Angela Steinauer

Angela Steinauer

Institute of Chemical Sciences and Engineering, EPFL

Angela Steinauer’s lab focuses on the engineering of non-viral, protein-based nanocarriers for targeted RNA delivery. Inspired by viral nucleic acid-protein assemblies, her group adopts a bottom-up approach and utilizes protein design, biomolecular engineering, and directed evolution to construct carriers with tailored functionalities.

Angela Steinauer
Nicolas Thomæ

Nicolas Thomä

ISREC – Swiss Institute for Experimental Cancer Research

The Thomä lab focuses on the structure and function of macromolecular machines at the interface of chromatin biology and ubiquitin biology. Recent work from the laboratory illustrated how transcription factor operate in the context of chromatin, and how endogenous and synthetic small molecules drive the degradation of transcription factors and other cellular proteins by leveraging the ubiquitin proteasome system.

Nicolas Thomä
Gerardo Turcatti

Gerardo Turcatti

BSF ACCESS, EPFL

The Academic Chemical Screening platform of Switzerland (ACCESS), led by Gerardo Turcatti, provides the scientific community with chemical diversity, screening facilities, medicinal chemistry and know-how in chemical genetics.

Gerardo Turcatti

Jérôme Waser

Laboratory of Catalysis and Organic Synthesis, EPFL

The principal focus of the research conducted by the Waser group is the development and application of new catalytic methods for the synthesis of bioactive compounds. His lab harnesses the power of modern catalysis to promote C-C or C-X bond formation, allowing for a rapid and efficient enhancement in molecular complexity.

Jérôme Waser
Winssinger

Nicolas Winssinger

Department of Organic Chemistry, UNIGE

The Winssinger lab makes use of small molecules and chemistry techniques to probe biological mechanisms. To accelerate probe discovery, the lab has pioneered DNA-encoded library technologies and has extended this technique to fold peptides in constricted conformations and are applying this approach to mimic affinity proteins.  Their research has also pioneered proximity-enabled chemistries and used it to image oligonucleotides in cellulo or in vivo, turn-on drugs in response to biomarkers and more generally develop methodology for logic-gated responses.  As part of this program, the Winssinger lab is developing photocatalytic reactions in chemical biology and using bioluminescence as a light source for photochemistry.

Nicolas Winssinger