About Nicolas Winssinger
Nicolas Winssinger received his B.Sc. in chemistry from Tufts University. He then carried out his doctoral studies under the tutelage of professor KC Nicolaou at The Scripps Research Institute (TSRI). After his PhD, he remained at Scripps to work in the group of professor P.G. Schultz as an NIH postdoctoral fellow. In 2002, he moved to the Institut de Science et Ingénierie Supramoléculaires (ISIS), Strasbourg University (formerly Université Louis Pasteur) as an assistant professor and was promoted to full professor in 2005. Shortly thereafter, he was elected to the Insitut Universitaire de France (IUF). In 2012 he moved to the University of Geneva where he currently is a Full Professor in the department of Organic Chemistry.
The Winssinger lab makes use of small molecules and chemistry techniques to probe biological mechanisms. To accelerate probe discovery, the lab has pioneered DNA-encoded library technologies with a focus on molecular discovery space that is under-represented in classical screening decks (covalent inhibitors, carbohydrates, lipids). Winssinger’s research has extended this technique to fold peptides in constricted conformations and are applying this approach to mimic affinity proteins. They have also pioneered proximity-enabled chemistries and used it to image oligonucleotides in cellulo or in vivo, turn-on drugs in response to biomarkers and more generally develop methodology for logic-gated responses. As part of this program, the Winssinger lab is developing photocatalytic reactions in chemical biology and using bioluminescence as a light source for photochemistry.