Sascha Hoogendoorn lab aims to study and perturb cellular signalling, with a particular interest in the primary cilium and the Hedgehog signalling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signalling.
The ultimate goal of Christian Heinis lab is the development of therapeutics by developing peptide macrocycles for potential therapeutic application using phase based strategy and biological and chemical tools. His lab currently develops potent antagonists to a range of disease targets, following medical indications in which bicyclic peptides promise advantages over small molecules and monoclonal antibodies.
Pierre Gönczy’s main research interests lie in understanding fundamental cell division processes, notably in the context of a developing organism and with a focus on the mechanisms governing centriole biogenesis and centrosome duplication as well as asymmetric cell division, a crucial phenomena for generating cellular diversity during development and in stem cell lineages.
The Loewith lab investigates the structures, functions and regulation of the two, broadly conserved, target of rapamycin (TOR) protein complexes. They use a combination of yeast genetics, cell biology, structural biology, chemical biology and biochemistry approaches and are particularly interested in how TOR complexes form higher order helical structures and how they are regulated downstream of mechanical changes in membrane tension.